The Autism-Inflammation-Infection Links

The Oxygen Model of the Autism Spectrum predicts that pathologic (disease-causing) inflammation from any source will worsen the signs and symptoms associated with spectrum.

My Oxygen Model of Autism is a unifying model that explains all aspects of autism on the basis of disruptions of oxygen homeostasis occurring during fetal life, infancy, and childhood. This model covers causes, clinical course, consequences, and control of clinical problems associated with the autism spectrum. It is based on a biologist’s holistic view of the brain development and neurotransmission. The autism spectrum is not a range of psychological or psychiatric disorders.

Inflammation of both healing and disease-causing types are governed by oxygen. The Oxygen Model of the Autism Spectrum predicts that pathologic (disease-causing) inflammation from any source will worsen the signs and symptoms associated with spectrum. This has been amply borne by my clinical experience. Parents of children on the spectrum under my care regularly recognize this connection regularly. The crucial clinical significance of this statement is: Every efforts should be made to detect and effectively address all sources of inflammation in all individuals on the spectrum, whether toddlers, children, teenagers, or adults.

Inflammation During Fetal Life
The Oxygen Model of Autism also predicts that exposure to the effects of maternal pathologic inflammation from any source will increase the risk of the unborn baby developing autism later in life. This was documented clearly by a study published online May 5 in The Journal of Autism and Developmental Disorders which fully validated my clinical observations with its study. Specifically, children of women who had a febrile illness during pregnancy were more than twice as likely as those who did not to develop autism and related developmental disorders. The study included 701 children with autism spectrum disorders or developmental delays and 421 normal controls.

In past reports, some data pointed to a connection between autism and various infections during pregnancy, including measles, mumps, rubella and influenza.


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